Author/Authors :
Kroes، نويسنده , , Roger A and Jastrow، نويسنده , , Aaron and McLone، نويسنده , , Michael G and Yamamoto، نويسنده , , Hirotaka and Colley، نويسنده , , Patricia and Kersey، نويسنده , , Donna S and Yong، نويسنده , , Voon Wee and Mkrdichian، نويسنده , , Edward and Cerullo، نويسنده , , Leonard and Leestma، نويسنده , , Jan and Moskal، نويسنده , , Joseph R، نويسنده ,
Abstract :
A two-step strategy was developed consisting of differential display reverse transcriptase polymerase chain reaction (DDRT-PCR) with cultured normal human fetal astrocytes and U-373MG glioma cells followed by reverse Northern analysis of normal brain and primary tumor tissues. hu-dek, α-NAC, ribosomal proteins L7a and L35a, and five novel genes were identified. Since none of these genes has been previously shown to be associated with malignant brain tumor formation, this approach may be useful to identify novel targets for the diagnosis and treatment of brain tumors.
