Title of article
Cytotoxity of non-alkaloidal taxane diterpenes from Taxus chinensis against a paclitaxel-resistant cell line
Author/Authors
Fukushima، نويسنده , , Masao and Fukamiya، نويسنده , , Narihiko and Okano، نويسنده , , Masayoshi and Nehira، نويسنده , , Tatsuo and Tagahara، نويسنده , , Kiyoshi and Zhang، نويسنده , , Shun-Xiang and Zhang، نويسنده , , De-Cheng and Tachibana، نويسنده , , Yoko and Bastow، نويسنده , , Kenneth F. and Lee، نويسنده , , Kuo-Hsiung، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
151
To page
154
Abstract
Seven taxane diterpenes were isolated from the EtOH extract of the aerial parts of Taxus chinensis, and evaluated for cytotoxicity against nine human cell lines, including a β-tublin mutant resistant to paclitaxel. Compound 2, a non-alkaloid-type taxane diterpene, showed significant cytotoxicity in most cell lines, and notably, equipotent against both parental and β-tublin mutant tumor cell lines.
Keywords
cytotoxicity , Non-alkaloid type taxane diterpene , ?-Tublin mutant tumor cell line
Journal title
Cancer Letters
Serial Year
2000
Journal title
Cancer Letters
Record number
1801744
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