Author/Authors :
Nakamura، نويسنده , , Ken-ichi and Furugori، نويسنده , , Eiki and Esaki، نويسنده , , Yukiyoshi and Arai، نويسنده , , Tomio and Sawabe، نويسنده , , Motoji and Okayasu، نويسنده , , Isao and Fujiwara، نويسنده , , Mutsunori and Kammori، نويسنده , , Makoto and Mafune، نويسنده , , Ken-ichi and Kato، نويسنده , , Motonobu and Oshimura، نويسنده , , Mitsuo and Sasajima، نويسنده , , Koji and Takubo، نويسنده , , Kaiyo، نويسنده ,
Abstract :
The hypothesis that telomeres in colorectal cancer cells exhibit age-related shortening, as in normal cells of the colorectal epithelium, was tested with samples of non-cancerous mucosa and cancer tissue from 124 patients (aged 29–97 years). Shortening with aging could be demonstrated for both normal and cancer tissues; regression analysis showed rates for length reduction of 44 and 50 base pair/year, respectively. Straight, essentially parallel, lines were obtained for the two cases, normal tissue values being about 2 kilobase pairs (kbp) higher, with a significant correlation between data at the individual patient level.
Keywords :
aging , colon carcinoma , Telomere shortening , Large intestine
