Author/Authors :
Seo، نويسنده , , Won-Gil and Pae، نويسنده , , Hyun-Ock and Kim، نويسنده , , Na-Young and Oh، نويسنده , , Gi-Su and Park، نويسنده , , In-Sik and Kim، نويسنده , , Yoo-Hyun and Kim، نويسنده , , Young-Myeong and Lee، نويسنده , , Young-haeng and Jun، نويسنده , , Chang-Duk and Chung، نويسنده , , Hun-Taeg Chung، نويسنده ,
Abstract :
The effects of water-soluble chitosan oligomers (WSCO) on the synthesis of nitric oxide (NO) by murine peritoneal macrophages and on macrophage-mediated cytotoxicity towards murine fibrosarcoma Meth A cells were investigated. WSCO alone had no effect on NO synthesis and killing of tumor cells. However, treatment of macrophages with a combination of WSCO and interferon-γ (IFN-γ) synergically increased NO synthesis and enhanced killing of tumor cells. The synergism between IFN-γ and WSCO in NO synthesis and tumoricidal activity was mainly dependent on increased secretion of tumor necrosis factor-α by WSCO.
Keywords :
Chitosan oligomers , Nitric oxide , Tumor necrosis factor-? , tumoricidal activity , macrophages
