Author/Authors :
Kiyota، نويسنده , , Akihisa and Shintani، نويسنده , , Satoru and Mihara، نويسنده , , Mariko and Nakahara، نويسنده , , Yuuji and Ueyama، نويسنده , , Yoshiya and Matsumura، نويسنده , , Tomohiro and Todd، نويسنده , , Randy A. Wong، نويسنده , , David T.W.، نويسنده ,
Abstract :
Epidermal growth factor receptor (EGFR) frequently overexpresses in cancers, including oral squamous cell carcinomas (OSCC). We previously identified a truncated EGFR (tEGFR) in human oral keratinocytes. In this study, we evaluated the prognostic value of tEGFR in 45 cases of OSCC. tEGFR expression inversely correlated with EGFR expression (r=−0.83, P<0.01), decreased with T-stage progression and lymph-node metastasis (P<0.05). The EGFR/tEGFR ratio correlated with the lymph-node metastasis (P<0.05) and survival outcome (hazard ratio =3.601; P<0.05). These results suggest that tEGFR may play an important roles in oral carcinogenesis and that the EGFR/tEGFR ratio may be a prognostic factor for OSCC.
