Title of article
Gene expression of GLUT isoforms and VHL in oral squamous cell carcinoma
Author/Authors
Fukuzumi، نويسنده , , Masakuni and Hamakawa، نويسنده , , Hiroyuki and Onishi، نويسنده , , Akiko and Sumida، نويسنده , , Tomoki and Tanioka، نويسنده , , Hioaki، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
8
From page
133
To page
140
Abstract
In human oral squamous cell carcinoma (OSCC) cell lines, we detected atypical mRNA expression of GLUT2 and/or GLUT4 in addition to enhanced expression of GLUT1 mRNA using RT-PCR. In semi-quantitative reverse transcription-polymerase chain reaction analysis of mRNA expression in OSCC cell lines, we found an inverse relationship between mRNA expression of von Hippel-Lindau (VHL) and that of GLUT1, with no apparent influence on the expression of other GLUTs. These findings suggest that the reduction of VHL may play a critical role in glucose uptake of OSCC cell lines, with enhancement of GLUT1 expression.
Keywords
Glucose transporter , Oral epithelial cell , Oral squamous cell line , von Hippel-Lindau
Journal title
Cancer Letters
Serial Year
2000
Journal title
Cancer Letters
Record number
1801964
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