Title of article
Alteration in the expression of protein kinase C isoforms in human hepatocellular carcinoma
Author/Authors
Tsai، نويسنده , , Jen-Hsiang and Hsieh، نويسنده , , Yih-Shou and Kuo، نويسنده , , Shou-Jen and Chen، نويسنده , , Shou-Tung and Yu، نويسنده , , Shi-Yau and Huang، نويسنده , , Chih-Yang and Chang، نويسنده , , Ai-Chi and Wang، نويسنده , , Yi-Wei and Tsai، نويسنده , , Min-Ting and Liu، نويسنده , , Jer-Yuh Liu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
5
From page
171
To page
175
Abstract
This study was designed to investigate the alterations of individual protein kinase C (PKC) isoforms in human liver cancer. Surgical specimens of hepatocellular carcinoma and adjacent normal tissues were extracted into cytosolic and membranous fractions. The level of membrane-bound PKCα in the cancer tissue was significantly lower than that in the adjacent normal tissue and consistent with the change in PKC activity. In addition, there was a significant negative correlation between PKCα and tumor size. In both cytosolic and membrane fractions, levels of PKCδ and PKCζ was significantly higher in the cancer tissue than those in the adjacent normal liver tissue. The alterations in the PKC isoforms signify their roles in the hyperproliferation in liver cancer.
Keywords
protein kinase C isoforms , Protein kinase C activity , Human hepatocellular carcinoma
Journal title
Cancer Letters
Serial Year
2000
Journal title
Cancer Letters
Record number
1801979
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