Author/Authors :
Jang، نويسنده , , Won Hee and Yang، نويسنده , , Young-Il and Yea، نويسنده , , Sung Su and Lee، نويسنده , , Youn Jae and Chun، نويسنده , , Jin Ho and Kim، نويسنده , , Hyeong-In and Kim، نويسنده , , Mi Seong and Paik، نويسنده , , Kyehyung and Rim Kim، نويسنده ,
Abstract :
We investigated the potential association of tumor necrosis factor-α (TNF-α) promoter polymorphisms with cancers. The study included 169 patients with gastric cancer, uterine cervical cancer, colorectal cancer, or renal cell carcinoma and 92 healthy controls. The -308 and -238 polymorphisms in the TNF-α promoter were analyzed by PCR-restriction fragment length polymorphism (RFLP). The proportion of individuals carrying the TNF-238A allele was significantly lower in the cancer group than in the control group. The odds ratio for cancer in subjects with the TNF-238A allele was 0.25 (95% CI, 0.10–0.64). No association was found between the -308 polymorphism and cancers. These results suggest that the -238A allele has a protective function against cancers.
