Author/Authors :
Akbar، نويسنده , , S.M.Fazle and Abe، نويسنده , , Masanori and Murakami، نويسنده , , Hidehiro and Tanimoto، نويسنده , , Kenji and Kumagi، نويسنده , , Teru and Yamashita، نويسنده , , Yoshimasa and Michitaka، نويسنده , , Kojiro and Horiike، نويسنده , , Norio and Onji، نويسنده , , Morikazu، نويسنده ,
Abstract :
The levels of macrophage migration inhibitory factor (MIF), a proinflammatory and carcinogenic cytokine, were significantly higher in the sera from patients with hepatocellular carcinoma (HCC; 25.6±15.3 ng/ml, n=55) and liver cirrhosis (LC; 18.9±10.7 ng/ml, n=26) compared with sera from patients with gastrointestinal cancer (6.8±7.5 ng/ml, n=29) and normal controls (5.6±1.2 ng/ml, n=45; P<0.01). Hepatocytes from patients with LC and HCC, but not from chronic hepatitis, expressed very high levels of MIF. A possible association between overexpression of MIF and hepatocarcinogenesis is suggested.
Keywords :
Cell culture , Migration inhibitory factor , hepatocellular carcinoma , liver cirrhosis , immunohistochemistry
