Author/Authors :
Frega، نويسنده , , A. and Stentella، نويسنده , , P. and Anceschi، نويسنده , , M.M. and Piazze، نويسنده , , J.J. and Tinari، نويسنده , , A. and Pach??، نويسنده , , A. and Cosmi، نويسنده , , E.V. and Marchionni، نويسنده , , M. and Villani، نويسنده , , C.، نويسنده ,
Abstract :
Acetowhitening of the vulva has been related to a subclinical human papillomavirus (HPV) infection. No consense has been reached about undertaking -or not- any therapy for these acetowhite changes. We have observed from our clinical experience and in a 10 years observational follow-up, that acetowhitening of the vulva regarding high risk (16–18) and low risk (6–11) HPV groups (as assessed by PCR analysis) significantly decreased; and acetowhitening areas negative to polymerase chain reaction (PCR), significantly increased from 53% (202/382) to 85% (276/325) (P<0.001). Our findings suggest that independently from HPV type and in the absence of cofactors, there is a statistically significant spontaneous remission of these areas.
