Title of article
Inhibitory effect of flavonoid derivatives on Epstein–Barr virus activation and two-stage carcinogenesis of skin tumors
Author/Authors
Iwase ، نويسنده , , Yukiko and Takemura، نويسنده , , Yuko and Ju-ichi، نويسنده , , Motoharu and Mukainaka، نويسنده , , Teruo and Ichiishi، نويسنده , , Eiichiro and Ito، نويسنده , , Chihiro and Furukawa، نويسنده , , Hiroshi and Yano، نويسنده , , Masamichi and Tokuda، نويسنده , , Harukuni and Nishino، نويسنده , , Hoyoku، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
5
From page
105
To page
109
Abstract
To search for possible anti-tumor promoters, ten flavonoid derivatives (1–10) synthesized from morin and quercetin were examined for their inhibitory effects on the Epstein–Barr virus early antigen (EBV-EA) activation by a short-term in vitro assay. Of these compounds, pentaallyl ethers (9, 10) showed significant inhibitory effects on EBV-EA activation induced by the tumor promoter, 12-O-tetradecanoylphorbol 13-acetate. Further, quercetin pentaallyl ether (10) exhibited remarkable inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test.
Keywords
Flavonoid derivative , Quercetin pentaallyl ether , Anti-tumor promoter , Two-stage carcinogenesis
Journal title
Cancer Letters
Serial Year
2001
Journal title
Cancer Letters
Record number
1803191
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