Author/Authors :
Iwase ، نويسنده , , Yukiko and Takemura، نويسنده , , Yuko and Ju-ichi، نويسنده , , Motoharu and Mukainaka، نويسنده , , Teruo and Ichiishi، نويسنده , , Eiichiro and Ito، نويسنده , , Chihiro and Furukawa، نويسنده , , Hiroshi and Yano، نويسنده , , Masamichi and Tokuda، نويسنده , , Harukuni and Nishino، نويسنده , , Hoyoku، نويسنده ,
Abstract :
To search for possible anti-tumor promoters, ten flavonoid derivatives (1–10) synthesized from morin and quercetin were examined for their inhibitory effects on the Epstein–Barr virus early antigen (EBV-EA) activation by a short-term in vitro assay. Of these compounds, pentaallyl ethers (9, 10) showed significant inhibitory effects on EBV-EA activation induced by the tumor promoter, 12-O-tetradecanoylphorbol 13-acetate. Further, quercetin pentaallyl ether (10) exhibited remarkable inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test.
Keywords :
Flavonoid derivative , Quercetin pentaallyl ether , Anti-tumor promoter , Two-stage carcinogenesis
