Author/Authors :
Oba، نويسنده , , Kouji and Konno، نويسنده , , Hiroyuki and Tanaka، نويسنده , , Tatsuo and Baba، نويسنده , , Megumi and Kamiya، نويسنده , , Kinji and Ohta، نويسنده , , Manabu and Kaneko، نويسنده , , Takeshi and Shouji، نويسنده , , Tsuyoshi and Igarashi، نويسنده , , Akira and Nakamura، نويسنده , , Satoshi، نويسنده ,
Abstract :
MMI-166 is a selective inhibitor of matrix metalloproteinase (MMP)-2 and MMP-9. Mice implanted a human colon cancer orthotopically received 200 mg/kg of MMI-166 orally for 5 weeks. Gelatin zymography demonstrated that the administration of MMI-166 remarkably decreased the active MMP-2 expression. Histological examination revealed that MMI-166 showed prominent effect on reduction of the invasive feature of the cancer cells and showed inhibitory effect on tumor vasculature, resulting in the significant decrease of microvessel density of the implanted tumor and liver metastasis compared with the control group. Conclusively, MMI-166 is a potent antiangiogenic oral agent for a human colon cancer.
Keywords :
MMI-166 , Colon cancer , Liver metastasis , Zymography , Microvessel density
