Title of article
Genetic alterations in endometrial hyperplasia and cancer
Author/Authors
Fabjani، نويسنده , , Gerhild and Kucera، نويسنده , , Elisabeth and Schuster، نويسنده , , Eva and Minai-Pour، نويسنده , , Michael and Czerwenka، نويسنده , , Klaus and Sliutz، نويسنده , , Gerhard and Leodolter، نويسنده , , Sepp and Reiner، نويسنده , , Angelika and Zeillinger، نويسنده , , Robert، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
7
From page
205
To page
211
Abstract
Putative precursors of endometrial cancer such as complex endometrial hyperplasia with atypia have been described to be monoclonal and considered to be genetically related. In order to identify a genetic marker that could serve as a putative predictor of endometrial cancer we analyzed 14 endometrial hyperplasia and 29 endometrial cancer samples for instabilities and loss of heterozygosity (LOH) in microsatellite sequences. Deletions on the short arm of chromosome 8 were frequently detected in both endometrial hyperplasia and cancer samples, suggesting that these deletions are early events in the development of endometrial cancer.
Keywords
Endometrial hyperplasia , Endometrial Cancer , microsatellite markers , POLYMERASE CHAIN REACTION , Loss of Heterozygosity
Journal title
Cancer Letters
Serial Year
2002
Journal title
Cancer Letters
Record number
1803394
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