Author/Authors :
Hwang، نويسنده , , Chung-Feng and Su، نويسنده , , Chih-Ying and Huang، نويسنده , , Shung-Chen and Huang، نويسنده , , Chao-Cheng and Fang، نويسنده , , Fu-Min and Lui، نويسنده , , Chun-Chung and Chang، نويسنده , , Hsueh-Wen and Cho، نويسنده , , Chung-Lung، نويسنده ,
Abstract :
To clarify the roles of p27 and c-myc in nasopharyngeal carcinoma (NPC), we used immunohistochemical studies to examine the expression of p27 and c-myc proteins in 69 patients with NPC. The results show that a low level of expression was observed in 47 and 41 cases, respectively. A low level of p27 expression was significantly correlated with loco-regional recurrence, and reduction in the c-myc protein was also correlated with neck metastasis in NPC. Our study indicates that a reduction in p27 expression is frequently seen in NPC. Furthermore, low expression levels of p27 and c-myc may contribute to the aggressive behavior of NPC.
