Author/Authors :
Ishikawa، نويسنده , , Takeshi and Yoshida، نويسنده , , Norimasa and Tokuda، نويسنده , , Harukuni and Ichiishi، نويسنده , , Eiichiro and Kuchide، نويسنده , , Masashi and Kokura، نويسنده , , Satoshi and Naito، نويسنده , , Yuji and Toyokuni، نويسنده , , Shinya and Nishino، نويسنده , , Hoyoku and Yoshikawa، نويسنده , , Toshikazu، نويسنده ,
Abstract :
Helicobacter pylori (H. pylori) infection has been associated with gastric carcinogenesis, but responsible and detail mechanisms are insufficient by the absence of adequate data. To obtain direct evidence regarding the carcinogenicity of H. pylori, we investigated the initiating and promoting activity of H. pylori water extract (HPE) in two-stage mouse skin carcinogenesis model. HPE treatment, as an initiation, significantly enhanced tumor formation compared with control group. Moreover, HPE treatment increased production of 8-hydroxydeoxyguanosine in epidermal cells and HPE-initiated/TPA-promoted papillomas demonstrated a point mutation of the Ha-ras gene. These results suggest an initiating activity of HPE on two-stage mouse skin carcinogenesis.
Keywords :
H. pylori , Mouse skin carcinogenesis , Initiating activity , Gastric cancer , Carcinogenesis
