Author/Authors :
Futami، نويسنده , , Hitoyasu and Egawa، نويسنده , , Shin-ichi and Takasaki، نويسنده , , Kayo and Tsukada، نويسنده , , Toshihiko and Shiraishi، نويسنده , , Masahiko and Yamaguchi، نويسنده , , Ken، نويسنده ,
Abstract :
We analyzed all 21 exons of the RET proto-oncogene of paired genomic DNA from tumors and normal tissues in 12 small cell lung cancer (SCLC) patients for the presence of genetic alteration. Polymerase chain reaction single-strand conformation polymorphism analysis and direct sequencing revealed that heterozygosity of the RET proto-oncogene was lost in the tumor tissues of six patients out of eight informative SCLC patients, although point mutation was not evident in any tumors. These results suggest that a deletion of the chromosomal region including the RET proto-oncogene is involved in the pathogenesis of SCLC.
