Title of article :
Effects of FK228, a novel histone deacetylase inhibitor, on tumor growth and expression of p21 and c-myc genes in vivo
Author/Authors :
Sasakawa، نويسنده , , Yuka and Naoe، نويسنده , , Yoshinori and Inoue، نويسنده , , Takeshi and Sasakawa، نويسنده , , Tatsuya and Matsuo، نويسنده , , Masahiko and Manda، نويسنده , , Toshitaka and Mutoh، نويسنده , , Seitaro، نويسنده ,
Abstract :
In this study, we examined the effects of FK228 (FR901228, depsipeptide) on tumor growth and expression of p21 and c-myc genes in vivo. FK228 induced the expression of p21 mRNA and decreased c-myc mRNA in tumor xenograft sensitive to FK228. However, FK228 did not sufficiently modulate the expression of p21 mRNA and increased the expression of c-myc in tumor xenograft less sensitive to FK228. The modulation of p21 and/or c-myc genes may be critical for the marked antitumor activity of FK228 in vivo.
Keywords :
FK228 , Xenograft , Tumor , c-Myc , p21
