Author/Authors :
Shoji، نويسنده , , Tuyoshi and Konno، نويسنده , , Hiroyuki and Tanaka، نويسنده , , Tatsuo and Sakaguchi، نويسنده , , Takanori and Sunayama، نويسنده , , Kenichi and Baba، نويسنده , , Megumi and Kamiya، نويسنده , , Kinji and Ohta، نويسنده , , Manabu and Kaneko، نويسنده , , Takeshi and Igarashi، نويسنده , , Akira and Nakamura، نويسنده , , Satoshi، نويسنده ,
Abstract :
The aim of the present study is to investigate the relation of cyclooxygenase (COX)-2 with liver metastasis. Pieces of human colon cancer xenograft were implanted orthotopically (CI), as well as intraperitoneally, and subcutaneously. Liver metastasis developed most frequently, and the COX-2 expression of both mRNA and protein of the tumors was the most dominant in the CI group. In contrast, the expression of COX-1 or vascular endothelial cell growth factor mRNAs had no significant differences among the groups. The intensity of COX-2 mRNA was negatively correlated with the apoptotic index. In conclusion, COX-2 plays an important role in organ-specific metastasis of the colon cancer.
