Author/Authors :
Miyaji، نويسنده , , Takahiro and Nakase، نويسنده , , Takanobu and Onuma، نويسنده , , Eturo and Sato، نويسنده , , Koh and Myoui، نويسنده , , Akira and Tomita، نويسنده , , Tetsuya and Joyama، نويسنده , , Susumu and Ariga، نويسنده , , Kenta and Hashimoto، نويسنده , , Jun and Ueda، نويسنده , , Takafumi and Yoshikawa، نويسنده , , Hideki، نويسنده ,
Abstract :
We investigated the effects of treatment with anti-parathyroid hormone-related protein (1–34) monoclonal murine antibody (anti-PTHrP MoAb) on apoptosis and the differentiation of chondrosarcoma HTB-94 cells. Treatment with anti-PTHrP MoAb accelerated apoptosis of HTB-94 cells in a dose-dependent manner, and anti-PTHrP MoAb also promoted the chondrogenic differentiation of HTB-94 cells. The induction of apoptosis by anti-PTHrP MoAb via imbalance of Bcl-2/Bax ratio and activation of caspase-3 may provide a mechanistic explanation for its potential antitumor effects. Our results suggest the possibility that anti-PTHrP MoAb may be beneficial as a new treatment for chondrosarcoma.
Keywords :
apoptosis , Chondrosarcoma , Anti-PTHrP MoAb , Differentiation , PTHrP
