Author/Authors :
Tanja M. Brueckl، نويسنده , , Wolfgang M and Heinze، نويسنده , , Elvira and Milsmann، نويسنده , , Catrin and Wein، نويسنده , , Axel and Koebnick، نويسنده , , Corinna and Jung، نويسنده , , Andreas and Croner، نويسنده , , Roland S and Brabletz، نويسنده , , Thomas and Günther، نويسنده , , Klaus and Kirchner، نويسنده , , Thomas and Hahn، نويسنده , , Eckhart G and Hohenberger، نويسنده , , Werner and Becker، نويسنده , , Heinz and Reingruber، نويسنده , , Bertram، نويسنده ,
Abstract :
Adenocarcinoma of the small intestine (ACSI) is a rare condition with few studies addressing follow-up and prognosis. Tumors of 35 patients with curative resection of an ACSI were retrospectively analyzed by immunohistochemistry: p53, hMLH1, hMSH2 and hMSH6 and microsatellite instability (MSI): BAT-26, BAX, TGF-β RII. With a median follow up of 6.1 years, the median cancer-specific survival (CSS) was 36.2 months. Patients who were highly instable (MSI-H) (n=10) had a CSS of 49.6 months in contrast to patients with stable tumors (23.2 months) (P=0.010). Additionally, a low tumor stage according to UICC and MSI-H were shown to be independent factors (P=0.005 and P<0.001) for an increased survival in multivariate analysis. Therefore, it is suggested that analysis of the MSI status might prove useful in discerning prognosis within cancers of the same stage.
Keywords :
microsatellite instability , Mismatch repair deficiency , Adenocarcinoma of the small intestine , Prognosis
