Author/Authors :
Yoon، نويسنده , , Jung-Hoon and Kim، نويسنده , , Youn Bae and Kim، نويسنده , , Myong Soo and Park، نويسنده , , Joo Cheol and Kook، نويسنده , , Joong-Ki and Jung، نويسنده , , Hae Man and Kim، نويسنده , , Saeng Gon and Yoo، نويسنده , , Hoon and Ko، نويسنده , , Yeong Mu and Lee، نويسنده , , Sang Ho and Kim، نويسنده , , Bong Young and Chun، نويسنده , , Hong Sung and Kanai، نويسنده , , Yoshikatsu and Endou، نويسنده , , Hitoshi and Kim-Mitsuyama، نويسنده , , Do Kyung، نويسنده ,
Abstract :
We have examined the expression and function of system l amino acid transporter in KB human oral epidermoid carcinoma cells. The KB cells express l-type amino acid transporter 1 (LAT1) in plasma membrane, but not l-type amino acid transporter 2 (LAT2). The [14C]l-leucine uptake by KB cells is inhibited by system l selective inhibitor BCH. The majority of [14C]l-leucine uptake is, therefore, mediated by LAT1. These results suggest that the transport of neutral amino acids including several essential amino acids into the KB cells mediated by LAT1 and the specific inhibition of LAT1 in oral cancer cells will be a new rationale for anti-cancer therapy.
Keywords :
KB human oral epidermoid carcinoma cells , Anti-cancer therapy , l-Type amino acid transporter , Essential amino acids
