Title of article
Expression and functional characterization of the system l amino acid transporter in KB human oral epidermoid carcinoma cells
Author/Authors
Yoon، نويسنده , , Jung-Hoon and Kim، نويسنده , , Youn Bae and Kim، نويسنده , , Myong Soo and Park، نويسنده , , Joo Cheol and Kook، نويسنده , , Joong-Ki and Jung، نويسنده , , Hae Man and Kim، نويسنده , , Saeng Gon and Yoo، نويسنده , , Hoon and Ko، نويسنده , , Yeong Mu and Lee، نويسنده , , Sang Ho and Kim، نويسنده , , Bong Young and Chun، نويسنده , , Hong Sung and Kanai، نويسنده , , Yoshikatsu and Endou، نويسنده , , Hitoshi and Kim-Mitsuyama، نويسنده , , Do Kyung، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
12
From page
215
To page
226
Abstract
We have examined the expression and function of system l amino acid transporter in KB human oral epidermoid carcinoma cells. The KB cells express l-type amino acid transporter 1 (LAT1) in plasma membrane, but not l-type amino acid transporter 2 (LAT2). The [14C]l-leucine uptake by KB cells is inhibited by system l selective inhibitor BCH. The majority of [14C]l-leucine uptake is, therefore, mediated by LAT1. These results suggest that the transport of neutral amino acids including several essential amino acids into the KB cells mediated by LAT1 and the specific inhibition of LAT1 in oral cancer cells will be a new rationale for anti-cancer therapy.
Keywords
KB human oral epidermoid carcinoma cells , Anti-cancer therapy , l-Type amino acid transporter , Essential amino acids
Journal title
Cancer Letters
Serial Year
2004
Journal title
Cancer Letters
Record number
1806145
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