Author/Authors :
Ishida، نويسنده , , Hideyuki and Miwa، نويسنده , , Hideaki and Tatsuta، نويسنده , , Masayuki and Masutani، نويسنده , , Seizo and Imamura، نويسنده , , Hiroshi and Shimizu، نويسنده , , Junzo and Ezumi، نويسنده , , Koji and Kato، نويسنده , , Hitoshi and Kawasaki، نويسنده , , Takatoshi and Furukawa، نويسنده , , Hiroshi and Kawakami، نويسنده , , Hitoshi، نويسنده ,
Abstract :
This study investigated the relationship between clinicopathological or immunohistochemical factors and postoperative prognosis for Dukesʹ C colorectal cancer. Short-term survivors died from cancer within 2 years of surgery, whereas long-term survivors were disease-free for over 10 years. The groups differed in Ki-67 antigen and CEA expression in colon cancer, and CEA expression in rectal cancer that was limited to the metastatic lymph nodes. The immunohistochemical scores were higher in short-term survivors. Our data suggest that the characteristics of metastatic lymph nodes are important as a predictor of the aggressiveness of tumor behavior and that the expression of Ki-67 antigen or CEA there may be a useful indicators of patientsʹ survival in Dukesʹ C colorectal cancer.
Keywords :
Ki-67 antigen , CEA , prognostic marker , Dukesי C colorectal cancer
