Title of article :
Correlation of p53 and bcl-2 expression with vascular endothelial growth factor (VEGF), microvessel density (MVD) and clinico-pathological features in colon cancer
Author/Authors :
Perrone، نويسنده , , G and Vincenzi، نويسنده , , B and Santini، نويسنده , , D and Verz??، نويسنده , , A and Tonini، نويسنده , , G and Vetrani، نويسنده , , A and Rabitti، نويسنده , , C، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Pages :
8
From page :
227
To page :
234
Abstract :
This study was designed to elucidate the possible relationship between tumour related genes and angiogenesis in colon cancer. The protein expression of p53, bcl-2, Von Willebrand factor and vascular endothelial growth factor (VEGF) were analysed by immunohistochemistry in 57 paraffin-embedded colon cancer. The results showed that microvessel density (MVD) was lower in VEGF negative tumours than in VEGF positive ones (P<0.0001). MVD and VEGF in p53 negative tumours were significantly lower than in p53 positive tumours (respectively, P=0.003 and P<0.0001). Moreover, positive correlations were recorded between VEGF expression and MVD, and bcl-2 expression (respectively, P<0.0001 and P=0.009). Our data confirm the central role of VEGF in angiogenesis and suggest direct correlations among p53, bcl-2 and VEGF expression in colon cancer.
Keywords :
Bcl2 , Vascular endothelial growth factor , Angiogenesis , p53
Journal title :
Cancer Letters
Serial Year :
2004
Journal title :
Cancer Letters
Record number :
1806420
Link To Document :
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