Author/Authors :
Tang، نويسنده , , Reiping and Wang، نويسنده , , Jeng-Yi and Fan، نويسنده , , Chung-Wei and Tsao، نويسنده , , Kuo-Chien and Chen، نويسنده , , Hong-Hua and Wu، نويسنده , , Chi-Ming and Chen، نويسنده , , Jinn-Shiun and Changchien، نويسنده , , Chung Rong and Hsieh، نويسنده , , Ling-Ling، نويسنده ,
Abstract :
One hundred and thirty-eight stage II and III colorectal cancer patients were included to evaluate the prognostic significance of genetic markers (including mutations of the p53, K-ras genes, and microsatellite instability) on the response to 5-fluorouracil (FU)-based post-operative adjuvant therapies (PAT). When stratified by PAT and adjusting for other prognostic variables, presence of p53 mutation was associated with a poor outcome (hazard ratio (HR)=3.1, 95% confidence interval (CI), 0.9–11.0) among patients without PAT. Our data confirmed that p53 mutation is an independent pre-treatment factor in stage II and III colorectal cancer after curative resection.
Keywords :
Colorectal Cancer , p53 mutation , K-Ras mutation , Post-operative adjuvant therapy
