Author/Authors :
An، نويسنده , , Yan and Gao، نويسنده , , Zenglin and Wang، نويسنده , , Zhongwen and Yang، نويسنده , , Shaohe and Liang، نويسنده , , Jianfen and Feng، نويسنده , , Yan and Kato، نويسنده , , Koichi and Nakano، نويسنده , , Masayuki and Okada، نويسنده , , Shoji and Yamanaka، نويسنده , , Kenzo، نويسنده ,
Abstract :
The appearance of 8-oxo-2′-deoxyguanosine (8-oxodG) was examined immunohistochemically using an 8-oxodG-monoclonal antibody in 28 cases of arsenic-related human skin tumors and in 20 cases of arsenic-unrelated human skin cancer to determine if the induction of oxidative stress participates in skin tumorigenesis caused by arsenics. The rate of 8-oxodG-positive was significantly higher in arsenic-related human skin cancer (28 of 28, 100%) than in arsenic-unrelated human skin cancer (3 of 20, 15%, P<0.01 by χ2 test). Moreover, in all the arsenic-related skin samples, 8-oxodG was detected not only in tumor tissues but also in keratosis and normal tissues. These results suggest that the induction of oxidative stress may play an important role in arsenic carcinogenesis.
Keywords :
Free radicals , 8-Oxo-2?-deoxyguanosine (8-oxodG) , Arsenic-related human skin cancers , oxidative stress
