Author/Authors :
Grützmann، نويسنده , , Robert and McFaul، نويسنده , , Christopher and Bartsch، نويسنده , , Detlef K. and Sina-Frey، نويسنده , , Mercedes and Rieder، نويسنده , , Harald and Koch، نويسنده , , Rainer and McCarthy، نويسنده , , Emma and Greenhalf، نويسنده , , William and Neoptolemos، نويسنده , , John P. and Saeger، نويسنده , , Hans Detlev and Pilarsky، نويسنده , , Christian، نويسنده ,
Abstract :
Familial pancreatic cancer (FPC) (approximately 3% of all cases) has not been linked to defects in any specific gene. Germline inactivation of the gene LKB1/STK11 have been shown to cause Peutz-Jeghers syndrome (PJS) associated with a ∼100-fold higher risk for the development of pancreatic cancer. We have analysed 39 index patients from European FPC families for mutations of LKB1/STK11 by sequencing of their DNA. No germline mutation was found within the complete coding region. Therefore, our results indicate that LKB1/STK11 is not altered in the germline of patients with hereditary pancreatic cancer.
Keywords :
STK11 , Familial pancreatic cancer , LKB1 , Hereditary cancer syndrome , Pancreas , cancer , mutation analysis
