Title of article :
Relation of epidermal growth factor receptor, phosphorylated-Akt, and hypoxia-inducible factor-1α in non-small cell lung cancers
Author/Authors :
Hirami، نويسنده , , Yuji and Aoe، نويسنده , , Motoi and Tsukuda، نويسنده , , Kazunori and Hara، نويسنده , , Fumikata and Otani، نويسنده , , Yu and Koshimune، نويسنده , , Ryuichiro and Hanabata، نويسنده , , Tetsuro and Nagahiro، نويسنده , , Itaru and Sano، نويسنده , , Yoshifumi and Date، نويسنده , , Hiroshi and Shimizu، نويسنده , , Nobuyoshi، نويسنده ,
Abstract :
The role of the epidermal growth factor receptor (EGFR)/Posphorylated-Akt (P-Akt) signaling axis in regulating hypoxia-inducible factor-1α (HIF-1α) expression in vivo is not well understood and is of potential clinical importance since the extent of hypoxia in the tumor environment is thought to be an important determination of resistance to chemotherapy and radiotherapy. We performed the immunohistochemical studies in 80 patients with non-small cell lung cancers to evaluate EGFR, P-Akt, and HIF-1α expression. Significant correlation between P-Akt and HIF-1α (P=0.0006) and marginal correlation between EGFR and P-Akt (P=0.066) were found. P-Akt was shown to be a poor prognostic factor as to patients with lymph node involvement (P=0.031).
Keywords :
P-Akt , HIF-1? , immunohistochemistry , EGFR , NSCLC
