Author/Authors :
Kinuya، نويسنده , , Seigo and Yokoyama، نويسنده , , Kunihiko and Izumo، نويسنده , , Mishiroku and Sorita، نويسنده , , Takami and Obata، نويسنده , , Takashi and Mori، نويسنده , , Hirofumi and Shiba، نويسنده , , Kazuhiro and Watanabe، نويسنده , , Naoto and Shuke، نويسنده , , Noriyuki and Michigishi، نويسنده , , Takatoshi and Tonami، نويسنده , , Norihisa، نويسنده ,
Abstract :
The efficacy of locoregional radioimmunotherapy (RIT) in treating peritoneal tumors of colon cancer of <2 mm in diameter was examined at maximum tolerated doses, focusing the comparison between 186Re and 131I labeled to an anti-colorectal cancer IgG1. Estimated radiation doses to tumors were considerably higher with 186Re-RIT than with 131I-RIT. The advantage of 186Re-RIT decreased with decreasing tumor size, but 186Re-RIT delivered 1.6-times higher radiation to tumors of 1 mm. Consequently, 186Re-RIT attained better survival of mice than 131I-RIT or chemotherapy with 5-fluorouracil did. Therefore, locoregional 186Re-RIT may be an option in an adjuvant setting of colon cancer with high risk of peritoneal dissemination.
Keywords :
186Re , Radioimmunotherapy , Colon cancer , Locoregional administration , Peritoneal metastasis
