Title of article
Analysis of combination anti-angiogenesis therapy on markers of coagulation, platelet activation and angiogenesis in patients with advanced cancer
Author/Authors
Caine، نويسنده , , G.J. and Harris، نويسنده , , A.L. and Christodoulos، نويسنده , , K. and Lip، نويسنده , , G.Y.H. and Blann، نويسنده , , A.D.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
163
To page
167
Abstract
The effects of combination anti-angiogenesis therapy (marimastat, captopril and fragmin) on plasma levels of coagulation initiator tissue factor (TF), platelet marker soluble P-selectin and angiogenic vascular endothelial growth factor (VEGF) were tested in 25 patients with advanced cancer. They had higher soluble P-selectin (P<0.001) and TF (P<0.001), but not VEGF (P=0.066) than 25 age and sex-matched controls. VEGF and TF correlated significantly (r=0.8, P<0.001) in cancer patients. Soluble P-selectin, TF and VEGF did not change at 4- and 8-weeks whilst on treatment. We provide further evidence linking coagulation and angiogenesis but combination anti-angiogenesis therapy does not influence plasma soluble P-selectin, TF or VEGF.
Keywords
Angiogenesis , Platelets , Soluble P-selectin , tissue factor , VEGF
Journal title
Cancer Letters
Serial Year
2005
Journal title
Cancer Letters
Record number
1807496
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