Title of article
Evidence for a general cancer susceptibility locus at 3p24 in families with hereditary prostate cancer
Author/Authors
Chang، نويسنده , , Bao-Li and Gillanders، نويسنده , , Elizabeth M. and Isaacs، نويسنده , , Sarah D. and Wiley، نويسنده , , Kathy E. and Adams، نويسنده , , Tamara and Turner، نويسنده , , Aubrey R. and Lilly Zheng، نويسنده , , and S. Mark Meyers، نويسنده , , Deborah A. and Carpten، نويسنده , , John D. and Walsh، نويسنده , , Patrick C. and Trent، نويسنده , , Jeffrey M. and Xu، نويسنده , , Jianfeng and Isaacs، نويسنده , , William B.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
6
From page
177
To page
182
Abstract
To identify genes that generally increase the risk of cancer, we performed a systematic search throughout the genome in 188 families primarily ascertained for prostate cancer but which also included individuals with other cancers. We observed significant evidence for linkage between susceptibility to all cancers and markers at 3p24, with a peak HLOD of 3.08 (P=0.0002). Compared to families with less than three other cancers and prostate cancer only, evidence for linkage at this region was stronger among families with at least three other cancers. This is the first reported example of a genome-wide search for general cancer susceptibility genes among hereditary prostate cancer families.
Keywords
hereditary , Genome-wide scan , prostate cancer , CANCER , linkage
Journal title
Cancer Letters
Serial Year
2005
Journal title
Cancer Letters
Record number
1807506
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