Author/Authors :
Niwa، نويسنده , , Yoshimitsu and Hirose، نويسنده , , Kaoru and Matsuo، نويسنده , , Keitaro and Tajima، نويسنده , , Kazuo and Ikoma، نويسنده , , Yoko and Nakanishi، نويسنده , , Toru and Nawa، نويسنده , , Akihiro and Kuzuya، نويسنده , , Kazuo and Tamakoshi، نويسنده , , Akiko and Hamajima، نويسنده , , Nobuyuki، نويسنده ,
Abstract :
To test the association of endometrial cancer with the p73 G4C14-to-A4T14 polymorphism in exon 2 and the p53 Arg72Pro polymorphism, an incident case-control study was performed in Japanese subjects. The cases comprised 114 endometrial cancer patients, and the controls were 320 healthy females and 122 noncancer female outpatients. An unconditional logistic regression model demonstrated a significant association between the p73 AA genotype and an increased risk of endometrial cancer (OR=2.82, 95% CI=1.36–5.82), especially of type-I tumors (OR=3.24, 95% CI=1.53–6.87). In contrast, there was no significant difference in the p53 Arg72Pro genotype frequency between the controls and cases.
Keywords :
Endometrial Cancer , p53 Arg72Pro polymorphism , Polymerase chain reaction with confronting two-pair primers , p73 two linked polymorphisms
