Title of article
Allelic imbalance of chromosome 1q in esophageal squamous cell carcinomas from China: a novel region of allelic loss and significant association with differentiation
Author/Authors
Li، نويسنده , , Jie and Liu، نويسنده , , Zhongmin and Wang، نويسنده , , Yunhai and Yu، نويسنده , , Zaicheng and Wang، نويسنده , , Mingrong and Zhan، نويسنده , , Qimin and Liu، نويسنده , , Zhihua، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
10
From page
221
To page
230
Abstract
Our previous work has shown that a number of genes locating on 1q21 were down-regulated in esophageal squamous cell carcinomas (ESCC) and they may involve in carcinogenesis. To determine whether chromosome 1q LOH occurs in ESCC, we analyzed LOH in 61 ESCCs using 18 microsatellite markers on chromosome 1q. Forty-six of 61 (75.4%) tumors presented LOH at one or more loci. A significant association was found between chromosome 1q LOH and histopathological grade. LOH on D1S3466 had a negative correlation with family history, whereas LOH on D1S2777 positively correlated with smoking. These results suggest this region harbor putative tumor suppressor gene(s) contributing to tumorigenesis and differentiation in ESCC.
Keywords
Esophageal squamous cell carcinomas , Chromosome 1q , Allelic imbalance
Journal title
Cancer Letters
Serial Year
2005
Journal title
Cancer Letters
Record number
1807650
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