Author/Authors :
Rieker، نويسنده , , Ralf J. and Aulmann، نويسنده , , Sebastian and Penzel، نويسنده , , Roland and Schnabel، نويسنده , , Philipp A. and Blaeker، نويسنده , , Hendrik and Esposito، نويسنده , , Irene and Morresi-Hauf، نويسنده , , Alicia and Otto، نويسنده , , Herwart F. and Hecker، نويسنده , , Erich and Dienemann، نويسنده , , Hendrik and Schirmacher، نويسنده , , Peter and Mechtersheimer، نويسنده , , Gunhild، نويسنده ,
Abstract :
Neuroendocrine (carcinoid) tumours of the thymus are rare neoplasms characterized by a highly malignant clinical behavior. Some of these tumors are associated with MEN1. In this study we evaluated 10 cases of sporadic thymic neuroendocrine tumours using immunohistochemistry and comparative genomic hybridization (CGH). All tumours showed a diffuse expression of neuron specific enolase (NSE) and synaptophysin. Chromosomal imbalances were detected in 8/10 cases, the most frequent gains were seen on chromosome Xp (3/10 cases), 7p, 7q, 11q, 12q, and 20q (2/10 each), losses were most frequently detected at 6q (5/10 each), 6p (3/10 each), 4q (3/10 each), 3p, 10q, 11q and 13 q (2/10 each). These CGH data show a degree of overlap with chromosomal imbalances commonly observed in advanced thymomas.
Keywords :
neuroendocrine tumour , Thymic carcinoid , Thymus , CGH
