Title of article
Inhibition of gastric cancer-associated angiogenesis by antisense COX-2 transfectants
Author/Authors
Fu، نويسنده , , Yuan-Gen and Sung، نويسنده , , Joseph JY and Wu، نويسنده , , Kai-Chun and Wu، نويسنده , , Han-Pin and Yu، نويسنده , , Jun and Chan، نويسنده , , Martin and Chan، نويسنده , , Victor YW and Chan، نويسنده , , Ka-Kui and Fan، نويسنده , , Dai-ming and Leung، نويسنده , , Wai K.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
10
From page
243
To page
252
Abstract
We characterized the effects of selective Cox-2 inhibition on the angiogenesis gastric cancer cell line SGC7901 by stable transfection of antisense Cox-2 cDNA (Cox-2-AS) or pharmacological inhibition by selective cox-2 inhibitor (NS398). The conditioned media obtained from SGC7901 treated with Cox-2-AS or NS398 suppressed the proliferation, migration and tube formation of human umbilical vein endothelial cells. Moreover, both treatments inhibited in vivo angiogenesis. These inhibitions could be partially reversed by the addition of PGE2. Our findings support that selective inhibition of Cox-2 alone plays an instrumental role on gastric cancer associated angiogenesis.
Keywords
Gastric cancer , Angiogenesis , Cyclooxygenase-2 , antisense
Journal title
Cancer Letters
Serial Year
2005
Journal title
Cancer Letters
Record number
1808103
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