Author/Authors :
Fu، نويسنده , , Yuan-Gen and Sung، نويسنده , , Joseph JY and Wu، نويسنده , , Kai-Chun and Wu، نويسنده , , Han-Pin and Yu، نويسنده , , Jun and Chan، نويسنده , , Martin and Chan، نويسنده , , Victor YW and Chan، نويسنده , , Ka-Kui and Fan، نويسنده , , Dai-ming and Leung، نويسنده , , Wai K.، نويسنده ,
Abstract :
We characterized the effects of selective Cox-2 inhibition on the angiogenesis gastric cancer cell line SGC7901 by stable transfection of antisense Cox-2 cDNA (Cox-2-AS) or pharmacological inhibition by selective cox-2 inhibitor (NS398). The conditioned media obtained from SGC7901 treated with Cox-2-AS or NS398 suppressed the proliferation, migration and tube formation of human umbilical vein endothelial cells. Moreover, both treatments inhibited in vivo angiogenesis. These inhibitions could be partially reversed by the addition of PGE2. Our findings support that selective inhibition of Cox-2 alone plays an instrumental role on gastric cancer associated angiogenesis.
Keywords :
Gastric cancer , Angiogenesis , Cyclooxygenase-2 , antisense
