Author/Authors :
Vajdovich، نويسنده , , Péter and Kriska، نويسنده , , Tamلs and Mézes، نويسنده , , Miklَs and Szabَ، نويسنده , , Piroska Ribiczey and Balogh، نويسنده , , Nلndor and Bلnfi، نويسنده , , Andrلs and Arany-Tَth، نويسنده , , Attila and Gaلl، نويسنده , , Tibor and Jakus، نويسنده , , Judit، نويسنده ,
Abstract :
Free radical and antioxidant parameters in healthy dogs (n=10) and dogs with non-Hodgkin lymphomas (n=11) were measured in blood and lymph node tissue samples before chemotherapy. Enzymatic and other biochemical measurements were performed. We found that (i) free radical concentrations based on ESR spectra of tissues correlated with higher proliferative character; (ii) lymphoma cases showed an impaired antioxidant status; (iii) tumors with low oxidative burst capacity and higher reduced/oxidized glutathione ratio responded better to chemotherapy; and (iv) affected blood and lymph nodes were under strong oxidative stress.
Keywords :
Free radicals , antioxidant , Canine lymphoma , MDR , Prognosis , oxidative burst
