Author/Authors :
Toshiyuki Onogawa، نويسنده , , Seiji and Kitadai، نويسنده , , Yasuhiko and Amioka، نويسنده , , Toru and Kodama، نويسنده , , Michiyo and Cho، نويسنده , , Songde and Kuroda، نويسنده , , Tsuyoshi and Ochiumi، نويسنده , , Takehiko and Kimura، نويسنده , , Shigeru and Kuwai، نويسنده , , Toshio and Tanaka، نويسنده , , Shinji and Chayama، نويسنده , , Kazuaki، نويسنده ,
Abstract :
In this study, we investigated whether expression of vascular endothelial growth factor (VEGF)-C and/or VEGF-D correlates with clinicopathological features of human gastric carcinoma. We immunohistochemically examined the expression of VEGF-C and VEGF-D in 140 archival surgical specimens of submucosally invasive gastric carcinoma. Of these specimens, 32 (22.9%) and 12 (8.6%) showed intense VEGF-C and VEGF-D immunoreactivity in cancer cells, respectively. VEGF-C immunoreactivity was associated with histological type, lymphatic invasion, lymph node metastasis, and microvessel density. No association was identified between VEGF-D immunoreactivity and clinicopathological variables. These results suggest that VEGF-C is a dominant regulator of lymphangiogenesis in early-stage human gastric carcinoma.
Keywords :
Gastric Carcinoma , Lymphangiogenesis , VEGF-C , VEGF-D
