Author/Authors :
Oki، نويسنده , , Eiji and Tokunaga، نويسنده , , Eriko and Nakamura، نويسنده , , Toshihiko and Ueda، نويسنده , , Naoyuki and Futatsugi، نويسنده , , Motonori and Mashino، نويسنده , , Kohjiro and Yamamoto، نويسنده , , Manabu and Watanabe، نويسنده , , Masayuki and Ikebe، نويسنده , , Masahiko and Kakeji، نويسنده , , Yoshihiro and Baba، نويسنده , , Hideo and Maehara، نويسنده , , Yoshihiko، نويسنده ,
Abstract :
Both PTEN (encoding phosphate and tensin homologue) and p53 are known as cancer suppressor genes, and they are assumed that their gene mutations and loss of heterozygosity (LOH) occur frequently in various types of carcinoma. In the present study, we investigated both the p53 mutation and LOH of PTEN in 113 gastric cancer patients. We observed the LOH of PTEN in 11.1% of the patients with normal p53s and 46.2% of the patients with p53 gene mutations. The result that LOH of PTEN was frequently observed in the cases with p53 gene mutations and other data in this study suggested that both PTEN and p53 have complimentary roles in gastric carcinoma development.
Keywords :
Loss of Heterozygosity , Gastric cancer , PTEN , p53
