Author/Authors :
Melancon، نويسنده , , K. and Cheng، نويسنده , , Q. and Kiefer، نويسنده , , T.L. and Dai، نويسنده , , J. and Lai، نويسنده , , L. and Dong، نويسنده , , C. and Yuan، نويسنده , , L. and Collins، نويسنده , , A. and Thiyagarajah، نويسنده , , A. and Long، نويسنده , , S. and Hill، نويسنده , , S.M.، نويسنده ,
Abstract :
A significant increase in tumor regression was induced in N-nitroso-N-methylurea-induced mammary tumors in rats treated with the combination of melatonin and 9-cis-retinoic acid (9cRA). Treatment groups included: control (ethanolic saline), 9cRA (30 mg/kg chow/day), melatonin 500 μg/day, melatonin 1000 μg/day, melatonin 500 μg/day+9cRA and melatonin 1000 μg/day+9cRA. Rats treated with the lower dose of melatonin 500 μg+9cRA show the greatest degree of tumor regression (78%), with 54% undergoing complete regression and a significant increase in apoptotic cells observed by TUNEL Assay. Furthermore, tumor multiplicity and burden were significantly decreased by the combination of melatonin and 9cRA.
Keywords :
melatonin , MT1 receptor , Retinoids , Regression , Breast tumor
