Title of article :
Glutathione peroxidase, glutathione-S-transferase, catalase, xanthine oxidase, Cu–Zn superoxide dismutase activities, total glutathione, nitric oxide, and malondialdehyde levels in erythrocytes of patients with small cell and non-small cell lung cancer
Author/Authors :
Kaynar، نويسنده , , Hasan and Meral، نويسنده , , Mehmet and Turhan، نويسنده , , Hamdullah and Keles، نويسنده , , Mustafa and Celik، نويسنده , , Gulnaz and Akcay، نويسنده , , Fatih، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
Lung cancer is a common pathology with high mortality due to late diagnosis. Glutathione peroxidase (GSH-Px), glutathione-S-transferase (GST), catalase (CAT), xanthine oxidase (XO), Cu–Zn superoxide dismutase (Cu–Zn SOD) activities, total glutathione (TGSH), nitric oxide (NO), and malondialdehyde (MDA) levels were investigated in erythrocytes of patients with non-small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC), and healthy control group. We aimed to investigate serum GSH, GSH-dependent enzymes activities (GSH-Px and GST), XO, CAT, Cu–Zn SOD activity, and NO, and MDA levels in patients with NSCLC and with SCLC and correlate with the cancer stage.
ocyte MDA, NO, TGSH levels and erythrocyte SOD, CAT and XO activities were significantly higher in patients with NSCLC and SCLC than in controls. Slightly increased erythrocyte GSH-Px and GST activities were not significantly different from the controls. Erythrocyte MDA level positively correlated with erythrocyte NO levels in patients with early stage (I+II) in NSCLC groups. Erythrocyte MDA level positively correlated with erythrocyte XO activity in patients with advanced stage (III+IV) in NSCLC groups. However, no other correlation could be found among the parameters in healthy controls and patients with NSCLC and with SCLC.
s obtained in this study indicate significant changes in antioxidant defence system in NSCLC and SCLC patients, which may lead to enhanced action of oxygen radical, resulting in lipid peroxidation.
Keywords :
Malondialdehyde , Superoxide Dismutase , Glutathione Peroxidase , Nitric oxide , Small cell and non-small cell lung cancer , glutathione
Journal title :
Cancer Letters
Journal title :
Cancer Letters