Author/Authors :
Hansen، نويسنده , , Rikke and Sوbّ، نويسنده , , Mona and Skjelbred، نويسنده , , Camilla Furu and Nexّ، نويسنده , , Bjّrn Andersen and Hagen، نويسنده , , Per Christian and Bock، نويسنده , , Günther and Bowitz Lothe، نويسنده , , Inger Marie and Johnson، نويسنده , , Egil and Aase، نويسنده , , Steinar and Hansteen، نويسنده , , Inger-Lise and Vogel، نويسنده , , Ulla and Kure، نويسنده , , Elin H. and Bjّrndal، نويسنده ,
Abstract :
Little is known about genetic risk factors for colorectal cancer. We assessed the association between polymorphisms in two genes involved in DNA repair of oxidative stress, GPX and OGG1, and risk of colorectal carcinoma or adenomas. We studied 166 cases with adenocarcinoma, 974 with adenomas and 397 controls recruited from the Norwegian cohort NORCCAP. No associations were found between the polymorphism GPX Pro198Leu and risk of colorectal adenomas or carcinomas. Carriers of the variant allele OGG1 Ser326Cys polymorphism had a lowered risk of colorectal cancer, OR=0.56 (95% confidence interval 0.33–0.95), while no association were found with risk of adenomas. This indicates that a low repair capacity of oxidative DNA damage may not be a risk factor for development of colorectal adenomas or carcinoma.
Keywords :
Dysplasia , carcinoma , oxidative stress , population based
