Title of article
Regulation of human peptide transporter 1 (PEPT1) in gastric cancer cells by anticancer drugs
Author/Authors
Inoue، نويسنده , , Mayumi and Terada، نويسنده , , Tomohiro and Okuda، نويسنده , , Masahiro and Inui، نويسنده , , Ken-ichi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
9
From page
72
To page
80
Abstract
Human peptide transporter 1 (PEPT1) mediates the cellular uptake of di- and tripeptides and peptide-like drugs in the small intestine. In the present study, we examined the regulation of PEPT1 by anticancer drugs in the gastric cancer cell line MKN45. PEPT1 was expressed and functioned in MKN45 cells. The transport activity and mRNA expression of the facilitative glucose transporter 1 (GLUT1) were significantly decreased by 5-fluorouracil treatment, but those of PEPT1 were slightly increased. Cisplatin treatment affected neither PEPT1 nor GLUT1 activity. In conclusion, PEPT1 expressed in MKN45 cells are resistant against the cellular injury induced by 5-fluorouracil and cisplatin.
Keywords
Gastric cancer , 5-fluorouracil , Peptide transporter , Cisplatin
Journal title
Cancer Letters
Serial Year
2005
Journal title
Cancer Letters
Record number
1808596
Link To Document