Title of article :
IgG antibodies to HPV16, 52, 58 and 6 L1-capsids and spontaneous regression of cervical intraepithelial neoplasia
Author/Authors :
Matsumoto، نويسنده , , Koji and Yasugi، نويسنده , , Toshiharu and Oki، نويسنده , , Akinori and Fujii، نويسنده , , Takuma and Nagata، نويسنده , , Chisato and Sekiya، نويسنده , , Souei and Hoshiai، نويسنده , , Hiroshi and Taketani، نويسنده , , Yuji and Kanda، نويسنده , , Tadahito and Kawana، نويسنده , , Takashi and Yoshikawa، نويسنده , , Hiroyuki، نويسنده ,
Abstract :
To identify the predictive markers for spontaneous regression of cervical intraepithelial neoplasia (CIN), we examined whether IgG antibody responses to common human papillomavirus (HPV) L1-capsids correlate with CIN regression. In a cohort study, a total of 116 Japanese women with CIN grade I/II were tested for cervical HPV DNA and serum IgG antibodies to HPV16/52/58/6 L1-capsids. Our data suggest that baseline IgG reactivities to HPV L1-capsids do not serve as a predictive marker of CIN regression, in contrast to histological CIN grades and HPV DNA status.
Keywords :
L1-capsids , CIN , VLP , HPV , Regression
