Title of article :
Chemopreventive effects of Paullinia cupana Mart var. sorbilis, the guaranل, on mouse hepatocarcinogenesis
Author/Authors :
Fukumasu، نويسنده , , Heidge and Silva، نويسنده , , Tereza Cristina da and Avanzo، نويسنده , , José Luis F.C Lima، نويسنده , , Cyntia Esteves de and Mackowiak، نويسنده , , Ivone Isabel and Atroch، نويسنده , , André and Spinosa، نويسنده , , Helenice de Souza and Moreno، نويسنده , , Fernando Salvador and Dagli، نويسنده , , Maria Lucia Zaidan، نويسنده ,
Abstract :
Guaranل (Paullinia cupana) is originally from Amazon, Brazil. Its effects on mouse hepatocarcinogenesis have been investigated in this study. Mice were treated with N-nitrosodiethylamine (DEN), received three different doses of P. cupana added to commercial food, and euthanized after 25 weeks. Gross lesions were quantified, and preneoplastic lesions (PNL) were histologically measured. Cellular proliferation was evaluated by immunobloting for the proliferating cell nuclear antigen (PCNA). The incidence and multiplicity of macroscopic lesions were reduced. The PNL number and PCNA expression were reduced in the highest P. cupana dose. According to these results, guaranل presented inhibitory effects on DEN hepatocarcinogenesis in mice.
Keywords :
Paullinia cupana , Guaranل , chemoprevention , Liver , PCNA , Carcinogenesis
