Author/Authors :
Tawara، نويسنده , , Masayuki and Hogerzeil، نويسنده , , Simon J. and Yamada، نويسنده , , Yasuaki and Takasaki، نويسنده , , Yumi and Soda، نويسنده , , Hiroshi and Hasegawa، نويسنده , , Hiroo and Murata، نويسنده , , Ken-ichi Ikeda، نويسنده , , Shuichi and Imaizumi، نويسنده , , Yoshitaka and Sugahara، نويسنده , , Kazuyuki and Tsuruda، نويسنده , , Kazuto and Tsukasaki، نويسنده , , Kunihiro and Tomonaga، نويسنده , , Masao and Hirakata، نويسنده , , Yoichi and Kamihira، نويسنده , , Shimeru Kamihira، نويسنده ,
Abstract :
Based on statistical analysis of its age-dependent occurrence, a multi-step carcinogenesis model has been proposed for Adult T-cell Leukemia/Lymphoma (ATLL). We have previously reported that the deletion of the p16 gene is a key event in ATLL progression. In the current study, we report for the first time that the aberrations of p16 and p53 are mutually exclusive in ATLL and either of the two events is sufficient for the ATLL progression. More than half of the patients had one of the two aberrations, and both aberrations emerged as significant markers for a poor prognosis.
Keywords :
Multi-step carcinogenesis , ATLL , Mutually-exclusive , p53 , P16
