Author/Authors :
Zhang، نويسنده , , Zhenhuan and Yamashita، نويسنده , , Hiroko and Toyama، نويسنده , , Tatsuya and Sugiura، نويسنده , , Hiroshi and Ando، نويسنده , , Yoshiaki and Mita، نويسنده , , Keiko and Hamaguchi، نويسنده , , Maho and Hara، نويسنده , , Yasuo and Kobayashi، نويسنده , , Shunzo and Iwase، نويسنده , , Hirotaka، نويسنده ,
Abstract :
The transcriptional function of estrogen receptor alpha (ERα) can be modulated by co-regulatory proteins. In the present study, therefore, the level of expression of one of the co-regulator Nuclear Receptor Co-repressor 1 (NCOR1) mRNA has been assessed by quantitative real-time RT-PCR in 160 cases of invasive breast carcinoma. It was found that NCOR1 mRNA was expressed at significantly higher levels in patients over 50 years of age, without axillary lymph node involvement, with tumor size less than 2 cm, with low or intermediate histological grade, with ERα/PgR-positive and with HER2 negative tumors. Patients with high levels of expression of NCOR1 mRNA have a better prognosis than those with low expression. Univariate and multivariate prognostic analysis demonstrated that NCOR1 mRNA is an independent prognostic factor for breast cancer.
Keywords :
breast cancer , Estrogen receptor , NCOR1 mRNA , progesterone receptor , Prognosis , real-time RT-PCR
