Author/Authors :
Suzuki، نويسنده , , Hiroyuki and Kawaguchi، نويسنده , , Takanori and Hasegawa، نويسنده , , Takeo and Yonechi، نويسنده , , Atsushi and Ohsugi، نويسنده , , Jun and Higuchi، نويسنده , , Mitsunori and Yamada، نويسنده , , Fumihiko and Shio، نويسنده , , Yutaka and Fujiu، نويسنده , , Koichi and Kanno، نويسنده , , Ryuzo and Ohishi، نويسنده , , Akio and Gotoh، نويسنده , , Mitsukazu، نويسنده ,
Abstract :
Prognostic value of p53 protein expression in node-negative lung adenocarcinoma is still controversy. The expression of p53 protein was examined immunohistochemically in lung adenocarcinoma using monoclonal antibody BP53-12. A total 131 cases of primary lung adenocarcinoma were examined. Relationship between expression of p53 protein and clinicopathologic factors were studied. Overexpression of p53 protein was found in 19 patients (14.5%). Univariate and multivariate analysis showed that overexpression of p53 protein was an independent prognostic factor in node-negative lung adenocarcinoma. p53 alteration could be a valuable predictor for prognosis in node-negative lung adenocarcinoma.
Keywords :
p53 protein , lung adenocarcinoma , Prognostic value , node-negative
