Title of article :
Enhanced photodynamic activity of hypericin by penetration enhancer N-methyl pyrrolidone formulations in the chick chorioallantoic membrane model
Author/Authors :
Saw، نويسنده , , Constance Lay Lay and Heng، نويسنده , , Paul Wan Sia and Chin، نويسنده , , William Wei Lim and Soo، نويسنده , , Khee Chee and Olivo، نويسنده , , Malini، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Pages :
7
From page :
104
To page :
110
Abstract :
Hypericin (HY) was examined for photodynamic therapy (PDT)-induced vascular damage using the chick chorioallantoic membrane (CAM) model. Clinically, plasma protein was used to solubilize HY. Upon binding to albumin, free HY available to be transported through the membrane may be limited. Hence, formulations containing a biocompatible solvent, N-Methyl pyrrolidone (NMP), have the potential to enhance HY delivery into solid tumors. At suitable concentrations, NMP and/or light irradiation did not produce antivascular damage. Hypericin-PDT effects showed to be HY and NMP concentrations-dependent. These findings indicate that NMP is a promising solvent and penetration enhancer for HY-PDT clinical applications.
Keywords :
Hypericin , Vasculature , formulation , Chick chorioalllantoic membrane , N-methyl pyrrolidone , photodynamic therapy
Journal title :
Cancer Letters
Serial Year :
2006
Journal title :
Cancer Letters
Record number :
1809435
Link To Document :
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