Author/Authors :
Inoue، نويسنده , , Takamitsu and Ito، نويسنده , , Takuo and Narita، نويسنده , , Shintaro and Horikawa، نويسنده , , Yohei and Tsuchiya، نويسنده , , Norihiko and Kakinuma، نويسنده , , Hideaki and Mishina، نويسنده , , Mutsuki and Nakamura، نويسنده , , Eijiro and Kato، نويسنده , , Tetsuro and Ogawa، نويسنده , , Osamu and Habuchi، نويسنده , , Tomonori، نويسنده ,
Abstract :
The association between four BCL10 single nucleotide polymorphisms at codons 5, 8, 162, and intron 1 and the susceptibility or progression for germ cell tumors (GCTs) was investigated in 73 testicular GCT patients and 72 controls. GCT patients with metastatic disease were more likely to have a variant type allele of the polymorphisms at codon 5 (age-adjusted odds ratio (aOR)=6.25; 95% CI=1.09–35.83; P=0.040) and codon 8 (aOR=4.63; 95% CI=1.35–15.93; P=0.015) than those with the localized disease. Therefore, BCL10 polymorphisms at codons 5 and 8 may play a role in the progression to advanced stage GCTs.
