Title of article
Delivery of hypericin for photodynamic applications
Author/Authors
Saw، نويسنده , , Constance Lay Lay and Olivo، نويسنده , , Malini and Soo، نويسنده , , Khee Chee and Heng، نويسنده , , Paul Wan Sia، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
8
From page
23
To page
30
Abstract
Early cancer detection is critical in improving disease management outcomes. Cancer diagnosis presents unique difficulties mainly due to its pathological presentation and poor accessibility that could limit the usefulness of conventional white light endoscopy in early cancer detection. Fluorescence endoscopy has been proven to improve the sensitivity and specificity of early cancer detection. Hypericin (HY) has been found to be superior to 5-aminolevulinic acid (5-ALA) and its ester derivative hexaminolevulinate (HA) as a fluorescence diagnostic agent, hence its development for delivery in vitro and in vivo, is the subject of this review.
Keywords
Hypericin , 5-Aminolevulinic acid , Hexaminolevulinate , Uptake mechanism , Photosensitizer , Fluorescence endoscopy , Delivery , Photodynamic , Cancer detection
Journal title
Cancer Letters
Serial Year
2006
Journal title
Cancer Letters
Record number
1809672
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