Author/Authors :
Wang، نويسنده , , Guanghui and Chen، نويسنده , , Haifeng and Huang، نويسنده , , Minghui and Wang، نويسنده , , Naili and Zhang، نويسنده , , Jinchao and Zhang، نويسنده , , Yaou and Bai، نويسنده , , Ganrong and Fong، نويسنده , , Wang-Fun and Yang، نويسنده , , Mengsu and Yao، نويسنده , , Xinsheng، نويسنده ,
Abstract :
Methyl protodioscin (NSC-698790) is one of the main bioactive components in the traditional Chinese medicine Dioscorea collettii var. hypoglauca (Dioscoreaceae). In this study, we investigated the anti-proliferative effect of methyl protodioscin on the HepG2 cells and the mechanism of the induced cytotoxicity. Treatment of methyl protodioscin resulted in G2/M arrest and apoptosis in HepG2 cells. These effects were attributed to down-regulation of Cyclin B1 and the signaling pathways leading to up-regulation of Bax and down-regulation of BCL2, suggesting that methyl protodioscin may be a novel anti-mitotic agent.
